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Hiroaki Nozaki Selected Research

Cerebral Small Vessel Diseases

12/2022Patients with heterozygous HTRA1-related cerebral small vessel disease misdiagnosed with other diseases: Two case reports.
2/2020Hemorrhagic cerebral small vessel disease caused by a novel mutation in 3' UTR of collagen type IV alpha 1.
5/2018Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation.
1/2012[Consideration of the pathogenesis of CARASIL].
8/2011[Dementia: progress in diagnosis and treatment; Topics, V. Recent topics; 4. Detection of novel dementia-related genes; 2) Dysregulation of TGF-beta family signaling and hereditary cerebral small vessel disease: insight into molecular pathogenesis of CARASIL].
5/2011Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.
4/2009Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

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Hiroaki Nozaki Research Topics

Disease

13Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
11/2021 - 04/2009
7Cerebral Small Vessel Diseases
12/2022 - 04/2009
3Dementia (Dementias)
08/2011 - 11/2007
2CADASIL
08/2021 - 03/2013
2Alzheimer Disease (Alzheimer's Disease)
01/2008 - 11/2007
1Leukoencephalopathies
01/2023
1Myalgia
08/2022
1Contracture
08/2022
1Pain (Aches)
08/2022
1Fibrosis (Cirrhosis)
01/2020
1Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy
12/2018
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2016
1Proteostasis Deficiencies
01/2016
1Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
01/2016
1Hereditary Diffuse Leukoencephalopathy with Spheroids
01/2014
1Inborn Genetic Diseases (Disease, Hereditary)
03/2013
1Fabry Disease (Fabry's Disease)
03/2013
1Familial Cerebral Amyloid Angiopathy
03/2013
1Arteriosclerosis
06/2010
1Spondylosis
04/2009
1Alopecia (Baldness)
04/2009
1Brain Neoplasms (Brain Tumor)
02/2009
1Brain Diseases (Brain Disorder)
02/2009
1Disorders of Excessive Somnolence (Hypersomnia)
02/2009
1Craniocerebral Trauma (Head Injury)
02/2009
1Lewy Body Disease (Lewy Body Dementia)
11/2007
1Ataxia (Dyssynergia)
07/2007
1Protein S Deficiency (Deficiency, Protein S)
03/2006
1Venous Thrombosis (Deep-Vein Thrombosis)
03/2006
1Amnesia (Dissociative Amnesia)
03/2006
1Thrombosis (Thrombus)
03/2006

Drug/Important Bio-Agent (IBA)

6Peptide Hydrolases (Proteases)FDA Link
12/2022 - 06/2010
6High-Temperature Requirement A Serine Peptidase 1IBA
11/2021 - 01/2012
4Serine (L-Serine)FDA Link
12/2022 - 06/2010
4Proteins (Proteins, Gene)FDA Link
11/2021 - 01/2008
3Fibronectins (Fibronectin)IBA
01/2012 - 06/2010
3Transforming Growth Factor beta (TGF-beta)IBA
08/2011 - 04/2009
2Macrophage Colony-Stimulating FactorIBA
01/2023 - 01/2014
2Amyloid (Amyloid Fibrils)IBA
01/2020 - 01/2008
2Retinaldehyde (Retinal)IBA
03/2013 - 07/2007
2Presenilin-1IBA
01/2008 - 11/2007
1AntibodiesIBA
08/2022
1Intravenous Immunoglobulins (IVIG)FDA Link
08/2022
1candesartanIBA
11/2021
1Cysteine (L-Cysteine)FDA Link
08/2021
1Collagen Type IV (Type IV Collagen)IBA
02/2020
13' Untranslated Regions (3' UTR)IBA
02/2020
1Lamin Type B (Lamin B)IBA
12/2018
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2017
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2017
1Arginine (L-Arginine)FDA Link
01/2017
1DNA-Binding Proteins (DNA Binding Protein)IBA
01/2016
1Nonsense Codon (Nonsense Mutation)IBA
01/2012
1FurinIBA
01/2012
1Versicans (Versican)IBA
06/2010
1CollagenIBA
06/2010
1Transforming Growth Factor beta1 (TGF beta 1)IBA
06/2010
1SteroidsIBA
02/2009
1anti-aquaporin 4 autoantibodyIBA
02/2009
1OrexinsIBA
02/2009
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
01/2008
1Codon (Codons)IBA
11/2007
1Threonine (L-Threonine)FDA Link
11/2007
1Amyloid beta-PeptidesIBA
11/2007
1alpha-SynucleinIBA
11/2007
1Flavin-Adenine Dinucleotide (FAD)IBA
11/2007
1Warfarin (Coumadin)FDA LinkGeneric
03/2006
1Heparin (Liquaemin)FDA LinkGeneric
03/2006
1Glycerol (Glycerine)FDA LinkGeneric
03/2006

Therapy/Procedure

1Adrenalectomy
08/2022
1Therapeutics
02/2009